Repeated exposures to oxygen in the immature stage increase blood pressure in rats.

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Neonatal male Wistar rats were separated into two groups at 5 days of age, and were subjected to daily, 3-h exposure to oxygen (O2 group) or air (control group), respectively. The exposures were conducted in a translucent chamber using 100% O2 or room air. In this exposure system, PaO2 measured at 1-h exposure showed about 3-fold increase, whereas PaCO2 and pH were not changed. Blood pressure measurement with tail-cuff method, which was conducted following 7-or 9-week exposure, revealed a significant increase in blood pressure in the O2 group compared to that in the control group. SOD activity and lipid peroxide in blood, as measured after 9-week exposure, were tended to be higher in the O2 group than in the control group, but the difference was not significant. The kidney weight was significantly smaller in the O2 group than in the control group, but light microscopic study showed no significant changes in both groups. The results suggest that repeated exposures to oxygen in the immature stage cause long-term changes in cardiovascular functions.
日本生気象学会の論文