Seasonal change in the levels of human serum phosphate, bromide, nitrate, and sulphate.

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Except for routinely determined serum chloride, carbonate and phosphate, there are few experiments dealing with the levels of inorganic anions. In this paper, the levels of serum inorganic anions in healthy volunteers were determined by ion chromatographic method and seasonal changes were examined. Blood samples were always collected in early morning (A.M. 6: 00 from April to November and A.M. 6: 30 from December to March) from a group of 13 males (mean age; 21.5 years) awoke and kept at rest in bed. 1. The serum phosphate values measured by ion chromatographic method well correlated with the values by colorimetric assay, although the values by ion chromatographic method were slightly higher. 2. The levels of serum inorganic anions in healthy volunteers were as follows: phosphate; 0.801mmol/l-1.702mmol/l (mean 1.311mmol/l), bromide; 0.043mmol/1-0.121mmol/l (mean 0.081mmol/l), nitrate; 0.025mmol/l-0.249mmol/l (mean 0.102mmol/l), and sulphate; 0.205mmol/l-0.529mmol/l (mean 0.340mmol/l) . 3. Serum phosphate, bromide, nitrate and sulphate changed significantly with a circannual rhythm. Statistical significances (P<0.001; paired t-test) were observed in all inorganic anions between the highest monthly mean values and the lowest. Therefore, to compare the measurement values of serum inorganic anions, the season of serum collection must be considered.
日本生気象学会の論文