Quantitative Analysis of Skin Reaction by Reflectance Spectrophotometer. Acute Reaction Following Proton Therapy.:ACUTE REACTION FOLLOWING PROTON THERAPY
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Acute reactions induced by proton irradiation were measured using a reflectance spectrophotometer, which is commonly used in the printing and textile industries. In this method, the skin color was expressed by three parameters, lightness (L*), chroma (C*) and hue (h).<BR>At first, in order to evaluate the accuracy of this specrtophotometer, the skin color of a normal volunteer was measured 100 times. The values of the three parameters for normal skin were as follows (mean values and standard deviations), L*: 68.64±0.29, C*: 19.08±0.13, h: 69.41±0.76.<BR>The standard deviations with regard to L* and h, were considered to be sufficiently small when compared with the changes of these parameters (prefix:Δ) in the irradiated sites (ΔL*<-2.41, Δh<-2.00). In measurements of 24 unirradiated sites for 8 patients, there were no statistical differences between the values taken at four different times within a day (p>0.05). These results showed that the accuracy of this equipment was acceptable, even when the measurement was performed at different times.<BR>For irradiated skin, L* and h values significantly decreased with time (p<0.05), and the L*values were highly correlated with elapsed treatment days (/r/>0.6 by linear regression analysis). The h values had a relatively low linear correlation compared with L*. The C* values had no trends as the treatment period was extended.<BR>Among these parameters, the L* values were the most valuable for assessment of protoninduced skin reactions, and it was suggested that the L* values measured with this spectrophotometer were a useful index for showing biological effects induced by proton irradiation.<BR>Further experiments are needed to apply this method to quantify the biological effects induced by other forms of ionizing radiation.
- 一般社団法人 日本放射線腫瘍学会の論文
一般社団法人 日本放射線腫瘍学会 | 論文
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