High-Speed Genome Scanning Analysis Based on Automated Detection and Matching Spots in Autoradiogram Images of 2-D Gel Electrophoresis
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概要
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In this paper, we present the pattern analysis of autoradiogram images obtained in two-dimensional gel electrophoresis based on the RLGS (restriction landmark genome scanning) method [1]. On a RLGS autoradiogram image, several thousands of spots can be observed; one spot corresponds to one genetic locus and its intensity reflects the copy number of the restriction landmark. In the first step of the computer analysis, geometricalocation and density of each spot was detected by applying some kinds of operators, including gradient and ring operators, to the autoradiogram image. As the second step, structured features of the spot pattern was extracted and represented as structured graph. Two or more structured graphs can be matched and compared by computer efficiently, enabling high-speed and fully-automated scanning of genomic DNA.
- 日本バイオインフォマティクス学会の論文
日本バイオインフォマティクス学会 | 論文
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