USING TRANSCRIPTION FACTOR BINDING SITE CO-OCCURRENCE TO PREDICT REGULATORY REGIONS
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概要
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Transcription factors (TFs) bind to the regulatory regions of genes in a cooperative manner. This article describes a method to detect pairs of transcription factor binding sites which co-occur in known regulatory regions more often than expected by mere combination of the individual binding sites. We determine frequently co-occurring TF pairs and evaluate the method using known TF interactions.<BR>Furthermore we use co-occurrence scores to assess the regulatory potential of a sequence region by calculating a graph-based score. We show results for the score on known regulatory regions.
- 日本バイオインフォマティクス学会の論文
日本バイオインフォマティクス学会 | 論文
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