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A male patient of 21 of age was infected with Plasmodium falciparum resisted to chloroquine during his stay in Parawan Island, Philippines. Typical fever attacks occurred just after coming back to Japan and he was hospitalized. The patient turned to worse within a few days due to high fever attacks and acute increase of parasitemia even by oral administration of chloroquine, and then he was treated with quinine intravenously as well as orally, in combination with pyrimethamine and sulfamono-methoxine, which resulted to establish complete cure of this patient. Among his clinical course, such findings were positive in high grades as leucopenia, thrombocytopenia, prolongation of prothrombin time, decrease of fibrinogen, antithrombin III and fibrin degradation products (FDP) in blood. Highly activation of SK plasmin was also recognized. Thcse findings were resembled with DIC syndrcm even though withcut actualization in this catient. Food trrmfusicn, rrecTieatie n of corticosteroid ard hecarin were very useful for recovery from those situation.
日本熱帯医学会の論文