Immunoblot Analysis of Antigens from Parastrongylus cantonensis, P. costaricensis and P. malaysiensis using Serum Antibodies against P. cantonensis.
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概要
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<I>Parastrongylus cantonensis, P. costaricensis</I> and <I>P. malaysiensis</I> adult worm antigens were tested for cross-reactivities in immunoblots using sera from patients with parasitologically confirmed parastrongyliasis. Sera from <I>P. cantonensis</I>-infected patients with a high specificity for the 31 kDa diagnostic <I>P. cantonensis</I> antigen also cross-reacted with a corresponding component found in <I>P. costaricensis</I> and <I>P. malaysiensis</I> proteins. The immune sera consistently recognized a prominent immunogenic band with molecular weight of 31 kDa against the antigens prepared from the three <I>Parastrongylus</I> species. Sera obtained from other clinically related patients infected with <I>Gnathostoma spinigerum</I> and normal healthy control sera did not react with the 31 kDa protein from the three species of <I>Parastrongylus</I>. The crossreactivity observed in the immunoblots performed on serum samples from patients with <I>P. cantonensis</I> infection indicates that the three <I>Parastrongylus</I> species share the specific 31 kDa antigen. This crossreacting protein may also be applied for an immunodiagnosis of human infection with the other two species of <I>Parastrongylus</I> worms, viz. <I>P. costaricensis</I> and <I>P. malaysiensis</I>.
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