NUMERICAL ANALYSIS ON BEHAVIOR OF DRUG AEROSOL PARTICLES IN A NASOSINUS MODEL

概要

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Aerosol inhalation therapy is generally used for postoperative clinical care of sinusitis. To realize more effective aerosol therapy for drug delivery to the paranasal sinus, some physical parameters, such as spray angle, flow rate, and drug particle size were discussed with the drug deposition fraction by using a nasal model of postoperative medical care. The flow in the nasal cavity and the drug particle velocity were calculated by numerical analysis. The numerical results were obtained as follows : <BR>The ratio of the flow rate into the maxillary sinus and the inlet was almost 1.23-1.44% in the numerical analysis. The optimum spray angle was obtained as 45° and 60° for the ethmoid and maxillary sinuses, respectively. The drug deposition fraction varied from 0.072-0.248% for the maxillary sinus and changed to 0.002-0.032% at the ethmoid sinus respectively depending in the flow rate of the inhalant and the drop size of the drugs. The drug deposition fractions in the paranasal sinus, the middle nasal meatus, and the inferior nasal meatus were increased at the impaction parameter of 1, 500-2, 000. The drug deposition fraction was also increased in the paranasal sinus for the spray angle of 45°-60°.
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