THE EFFECT OF ASPIRIN AND PREDNISOLONE ON NASAL CILIARY ACTIVITY

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The effect of aspirin and prednisolon on the nasal ciliary activity (CA) was examined in vitro. CA was investigated by a photo-electric method using normal human ethmoid sinus mucosa and observed from 5 to 3 minutes in RPMI-1640 including aspirin and prednisolon. Results obtained were as follows: 1. In the medium 0.18%(1, 800mg/l), 0.36%(3, 600mg/l) aspirin, CA was increased after 5 minutes until after 30 minutes. On the other hand, in 0.72%(7, 200mg/l) of aspirin, CA was reduced in according to the time, and in 0.90%(9, 000mg/l) of aspirin, CA was immediately inhibited. 2. In addition of 0.05%(500 mg/l) or 0.10%(1, 000mg/l) prednisolone, CA was increased after 5minutes and showed a tendency of increase after 30 minutes. Although the mechanisms of efficacy of aspirin and prednisolone to CA remain unknown, our results suggest that they are effective drugs on CA at least.
耳鼻咽喉科展望会の論文