Evalution of olfactory epithelium affected by Tegafur.

概要

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Tegafur-induced olfactory disturbances were studied imunohistochenmically in guinea pigs using anti-BrdU antibodies. Tegafur was orally administered for 3 weeks. The results were as follows. 1) The number of cells taking up BrdU decreased with increasing doses of Tegafur. 2) There were no marked morphological changes such as atrophy of the olfactory epithelium or a decrease in the number of olfactory cells. Tegafur induced no marked morphological changes of the olfactory epithelium probably because the period of administration was only 3 weeks. However, the immunohistochemical observation using anti-BrdU antibodies revealed that dividing cells in the olfactory epithelium were inhibited in proportion to the dose of Tegafur. Continual inhibition was presumed to induce such morphological changes of the olfactory epithelium as have been observed in human cases.
耳鼻咽喉科展望会の論文