EXPERIMENTAL STUDY OF THE EFECT OF EMOTIONAL STIMULATION ON VESTIBULE OF THE EAR AND OPTOKINETIC FUNCTION
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概要
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Spontaneous and induced nystagmus elapsed-time tests were carried out with a nystagmograph and followed by pathohistological evaluation of the inner ear.<BR>Test Results:<BR>1. In all groups of rabbits, spontaneous nystagmus was not demonstrated in both light and dark areas.<BR>2. In the group not subjected to stress, the number of oscillations per eye in pendular nystagmus (PR) was not the same but the difference was within 10%, while in optokinetic nystagmus (OKN) this difference was greater but still within 12.2%.<BR>3. In the group subjected to chronic emotional stimulation, the difference between the right and left eyes was a maximum of 24.6%, while in OKN the difference was a maximum of 73.0%. Only one case showed a low frequency of nystagmus.<BR>4. In the group subjected to acute emotional stimulation, the difference in PR was 20.6% and in OKN 76.9%. Nystagmus appeared gradually following stimulation.<BR>5. In the group of rabbits placed under restraint, all animals showed an increased difference between right and left eyes in PR, or 69.6%, and a difference of 82.6% in OKN. Here, nystagmus was slow to appear following stimulation in some cases.<BR>6. In some of the animals in the groups subjected to chronic and acute emotional stimulation, pathohistological examination of the inner ear revealed unaccountable aural vertigo centering on Meniere's syndrome.<BR>There have been many theories advanced as the etiology of nystagmus. These have included one quite recently that such psychosomatic factors as the complexity of modern social structure and life exert a great influence. Where fundamental studies are concerned, a few experiments dealing with stress alone have been carried out, but none regarding the effect on vestibule of the ear and optokinetic function.<BR>For this reason, rabbits were subjected to various emotional stimulation and the various changes in spontaneous and induced nystagmus were observed, together with pathohistological evaluation.<BR>In order to carry out these experiments, a stress box was constructed in which animals could be subjected to electrical, light and sound stimulation and also to restraint.<BR>The experiments were classified into chronic and acute tests, on the basis of the strength and duration of the emotional stimulation, and the test where restraint alone was used.<BR>In other words, the rabbits were divided into four distinct groups: that where no stress was exerted, the chronic emotional stimulation group, the acute emotional stimulation group, and the restraint group.<BR>Some rabbits gave evidence of hemorrhage resulting from electrical stimulation, while all rabbits in the groups subjected to stress displayed changes in their adrenal glands. Rabbits in the groups subjected to emotional stimulation gave evidence of effects on the optokinetic functions and vestibule of the ear.<BR>The difference in oscillation rates between left and right eyes in cases of PR and OKN tended to increase with the increase in stimulation.<BR>Where spontaneous nystagmus did not appear, it was thought that a condition preparatory to the appearance of vertigo existed.
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