血糖値の適応制御システム

概要

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The adaptive blood glucose control system is presented to compensate in an on-line manner individual differences and parameter variations in the blood glucose regulation of diabetic subjects The glucose regulation behavior is described on a minute-by-minute basis as a linearized model with insulin and glucose control inputs and a blood glucose output. The blood glucose level is controlled to track a desired profile specified by a physician. The algorithm includes two kinds of controllers: a self-tuning regulator to adaptively perform a model-matching to the reference model, and a feedback controller to minimize the output error between the actual glucose level and the desired one, even in the presence of the modelling error as well as disturbances. It is clarified in numerical simulations that the control algorithm can work very efficiently in the case with imperfect knowledge on the dynamics of diabetics, compared with a conventional control scheme with fixed parameters. The efficiency is also examined in animal experiments using dogs.
公益社団法人計測自動制御学会の論文