Development of Agglomerated Crystals of Ascorbic Acid for Direct Tableting by Spherical Crystallization Technique and Evaluation of Their Compactibilities.
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概要
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Spherically agglomerated crystals of ascorbic acid for direct tableting were successfully prepared by the spherical crystallization technique. The micromeritic and compaction properties of the original ascorbic acid crystals were dramatically improved. The dominating mechanisms of improved compaction properties of the spherically agglomerated crystals depended on their fragmentation and plastic deformation during compaction. This mechanism was supported by higher stress relaxation and less elastic recovery of the compact of agglomerated crystals in comparison with the original crystals. The spherically agglomerated crystals were tableted directly without capping using a single punch machine under dynamic compaction, although the tensile strength of tablet with the spherically agglomerated crystals decreased with increasing compression speed.
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