Immunocytochemical studies on brain tumors.
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概要
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Immunocytochemical studies of 45 cases of brain tumors (astrocytoma·grade 27, pleomorphic xanthoastrocytoma 1, astroblastoma 1, anaplastic astrocytoma 8, glioblastoma 9, oligodendroglioma 4, ependymoma 1, meningioma 6, neurinoma 2, pituitary adenoma 3, metastatic carcinoma 3) were done using six antibodies of intermediate filaments and neuron specific proteins.<BR>GFAP was very useful to discriminate glial tumors and ependymoma from other tumors because glial tumors and ependymoma only were positive, and gliomas showed decrease in high-malignancy.<BR>Positive NFP seen in cases of glioblastomas and pituitary adenomas was considered to be due to dysdifferentiation.<BR>Positive Vimentin seen in gliomas, which reversely correlated with positivity of GFAP, was explained by dedifferentiation.<BR>Cytokeratin was very useful to discriminate metastatic carcinoma and pituitary adenomas from other primary brain tumors, because metastatic carcinomas and pituitary adenomas only were positive.<BR>NSE showed no specifically for a certain type of brain tumors.<BR>S-100 was very useful to discriminate neurinoma from meningioma, because the both cytologically resemble each another and neurinomas were intense positive and meningiomas were negative or feeble positive.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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