A Case of Benign Metastasizing Leiomyoma Diagnosed 10 Years After Hysterectomy
スポンサーリンク
概要
- 論文の詳細を見る
<B>Background.</B> Benign metastasizing leiomyoma (BML) is a rare entity among leiomyomas in the lung. Most cases had previously undergone hysterectomy for uterine leiomyoma, but the pathogenesis and biology have not been elucidated yet. In this paper, we report a case of BML found 10 years after hysterectomy along with the results of immunohistochemical analyses of both the lung nodule and uterine tissue specimens. <B>Case.</B> A 53-year-old woman was found to have an abnormal shadow on a chest X-ray film and was referred to our hospital for further evaluation. Chest CT scan showed multiple smoothly marginated nodules 3 to 18 mm in diameter in bilateral lung fields. Although metastatic lung cancer was suspected, no primary lesion was detected. Thoracoscopic lung biopsy was performed, and the diagnosis of BML was made histopathologically. To attempt to clarify the pathogenesis of BML, immunohistochemical analyses of estrogen receptor (ER), progesterone receptor (PgR), p53, Bcl-2, and Ki-67 of both lung nodules and uterus tissue specimens were performed. Both tissues stained positively for ER, PgR, and Bcl-2, but both were negative for p53 and Ki-67. <B>Conclusion.</B> Immunohistochemical analyses revealed similar results from both the lung nodule and uterus tissue. In particular, ER and PgR were positive in both tissues, suggesting a role of sex hormones in the pathogenesis of BML. Although BML is rare, it should be considered as a possible differential diagnosis when multiple nodules occur within the lung associated with a history of uterine leiomyoma.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
- 診療科からみた新しいTNM病期分類（UICC-7）の問題点と課題?画像診断からみた問題点と課題?
- 新潟県における肺がんの解析
- 慢性血栓塞栓性肺高血圧症合併肺腺癌に対する左上葉切除術を施行した1例
- 肺がん検診における判定基準の改訂（2）：B，C，D判定に関して
- 片側性多発脳神経障害（Garcin症候群）を契機に発見され，化学療法により神経症状の改善を得た小細胞肺癌の1例