Pathogenesis of Pulmonary Infarction Following Lung Tumor With Regard to the Presence of Venous Infarction.

概要

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Objective: To reevaluate the pathogenesis of pulmonary infarction following lung tumors, after an experience with venous infarction. To date, pulmonary infarction is considered arterial, especially pulmonary thrombo-embolism. Subjects and Methods: Twenty-six patients with pulmonary infarctions following lung tumors among 594 lobectomies and one surgical lung biopsy. Patients with infarction consisted of 21 men and 6 women and the mean age was 59. Pulmonary infarctions were divided into arterial, mixed, and venous according to the degree of arterial and venous obstruction or stenosis and location of the infarction; centrilobular or centri-septal. Infarctions were evaluated macroscopically and microscopically and scored semi-quantitatively. Results: There were 7 arterial, 16 mixed, and 4 venous infarctions. Although marked overlaps existed among all three groups, the degree of arterial lesions (2.7±0.5: 1.3±0.5) and venous lesions (0.7±0.5: 2.8±0.5) around the infarction significantly differed (<5%) between the arterial and venous infarction groups. There was no thrombus in or around fresh infarction. The location of infarction (centrilobular: centriseptal) was also significantly different (<1%) between the two groups (arterial 5: 0, venous 0: 13). Conclusion: Recognition of venous infarction is important in understanding the pathogenesis of pulmonary infarction.
特定非営利活動法人日本肺癌学会の論文