Integrins .ALPHA.2.BETA.1, .ALPHA.5.BETA.1 and .ALPHA.v.BETA.5 Are Related to Tumor Growth and Metastasis of Non-small Cell Lung Cancer.
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<B>Objective</B>: Integrins are related to the growth, invasion, and metastasis of cancer cells, and lung cancer cellsexpress multiple integrin subunits. This study was designed to determine the integrin subunits which playmajor roles in the growth and metastasis of non-small cell lung cancer (NSCLC).<BR><B>Methods</B>: NSCLC cell lines EBC-1, LK-2, LC-1F, PC-14, PC-3, VMRC-LCD and IA-5 were transplanted into athymic mice both subcutaneouslyand intravenously. Subcutaneous tumor sizes were measured twice a week. Carcinoma cells from evidentmetastatic lesions were obtained and cultured. The patterns of integrin subunit expression were evaluatedusing immunofluorescence flowcytometric analysis.<BR><B>Results</B>: Maximal subcutaneous tumor size in theexponential growth phase was negatively correlated with integrin α5 and β1 expression (p=0.028, p=0.035). Three months after transplantation, carcinoma cells from 11 evident metastatic lesions were obtained andcultured. Expression of integrins α1, α2, α3, α4, α5, α6, αv, β1, β3, β4 and β5 was evaluated by flowcytometry. Expression of integrins α2, α3, α5, α6, β1, β4 and β5 was commonly detected inoriginal cell lines. The evidentchanges at the sites of metastasis were increases in α2 (p=0.04), αv (p=0.05), β1 (p=0.008) and β5 (p=0.09) expression. <B>Conclusion</B>: These results suggest that integrins α2β1 and αvβ5 are related to metastasis, and that α5β1 isrelated to tumor growth of NSCLC.
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