Outcome of Serological Tests for Mycosis in Patients with Lung Cancer during Febrile Episodes.

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Clinical evaluation of deep mycosis in patients with lung cancer has not been clarified. Various serological tests for mycosis were performed to clarify the significance of mycosis in the patients. We performed measurement for Candida antigen in patients with lung cancer during febrile episodes: heat-labile glycoprotein was measured by the latex agglutination test (Cand-Tec), Aspergillus antigen by the latex agglutination test (Pastorex Aspergillus), D-arabinitol/creatinine ratios and β-D-glucan were tested by the G-test. Furthermore, the results of various serological tests were compared with those of blood cultures. Candida antigen and D-arabinitol/creatinine ratios were positive in 38 and 10 specimens, respectively. Aspergillus antigen was positive in two patients and β-D-glucan was positive in 16 patients. Candida sp. was, however, cultured from their blood in only 5 samples, thus care must be taken in interpreting the results. Deep mycosis was diagnosed by the results of serological tests and blood cultures in 15 episodes in 10 patients, which accounted for 20% of the febrile episodes. Conclusion: The importance of serological tests was demonstrated, however the results were not totally satisfactory from the clinical point of view. New techniques, for example PCR method, are needed to diagnose invasive fungal infections.
特定非営利活動法人日本肺癌学会の論文