A Case of Large Cell Carcinoma of the Lung with Remarkably Elevated Level of Serum CEA, Successfully Treated by Combined Therapy.

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A 52-year-old man with a complaint of cough and sputum was referred to our hospital because of an abnormal shadow in the left upper lung field on chest X-ray films. The serum CEA level was 352.9 ng/ml. Cytological examination of a needle biopsy specimen revealed non-small cell carcinoma. The clinical stage was stage IIIB (T3N3αM0). The patient underwent surgery after induction chemotherapy. Left upper lobectomy and bilateral mediastinal dissection was performed via median sternotomy and an anterolateral incision. Histopathological examination demonstrated large cell carcinoma without lymph node metastasis (ypT3N0M0). The patient received 50 Gy of irradiation to the superior mediastinum because the surgical margin was histologically positive. After these treatments, the serum CEA level returned to normal. No recurrence has been detected and the serum CEA level has remained normal for 28 months postoperatively.
特定非営利活動法人日本肺癌学会の論文