Cytologic Characteristics of Adenocarcinoma of the Lung in Relation to Response to Chemotherapy.

概要

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Cytologic features of adenocarcinoma of the lung in relation to response to chemotherapy were studied. Twenty-six patients underwent more than 2 courses of intensive chemotherapy with cisplatin and vindesine. Among them, 9 patients showed partial response (PR), 11 patients showed no change (NC) and these were 6 cases of progressive disease (PD). Cellular characteristics of adenocarcinoma cells obtained directly from tumors were examined in terms of the size of cells and nuclei, nuclear shape, chromatin pattern, and nucleoli features. The adenocarcinoma cells which appeared more frequently in the PR group were characterized by a large, round nucleus with fine reticular chromatin evenly distributed. The adenocarcinoma cells which appeared more often in the NC group had a small irregular nucleus with sparse chromatin unevenly distributed and a solitary small nucleolus. Adenocarcinoma cells with coarse chromatin appeared more ofter in the PD group.<BR>Cytologic characteristics of adenocarcinoma cells of the lung indicate the probable response to chemotherapy.
特定非営利活動法人日本肺癌学会の論文