Expression of Glutathione S-transferase-pi (GST-pi) and Metallothionein (MT) in Lung Cancer.

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It has been suggested that glutathione S-transferase-pi (GST-π) and metallothionein (MT), which are an intracellular detoxification enzyme and detoxification protein, are contribute to anti-cancer drug resistance. In present study, GST-π and MT expression was analyzed immunohistochemically in primary tumors from 97 patients with lung cancer and the relationship with the results of chemotherapy was examined. Of 56 previously untreated non-small cell lung cancer, 86% were positive for GST-π, which was significantly higher than the degree for small cell lung cancer (P<0.0001). All 8 previously untreated small cell lung cancer were negative for GST-π and 78% of 18 small celllung cancer cases receiving preoperative chemotherapy with a regimen including cisplatin were positive. GST-π was found to be induced after chemotherapy (P=0.0003). Of 56 previously untreated non-small cell lung cancers 27% were positive for MT and 80% of 15 non-small cell lung cancer received preoperative chemotherapy were positive. MT was significantly induced after chemotherapy (P=0.0005). We therefore suggest that GST-π is an important tumor marker of non-small cell lung cancer, which is significantly induced after chemotherapy and related to drug resistance.
特定非営利活動法人日本肺癌学会の論文