Leptomeningeal Carcinomatosis in Patients with Lung Cancer.

概要

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Out of a total of 1586 lung cancer cases treated since1977, 22 cases clinically diagnosed to have leptomeningeal carcinomatosis (LMC) wereexamined. The incidence was 1.4%, and the frequency of LMC in small cell carcinoma was significantly higher than in adenocarcinoma or squamous cell carcinoma. The diagnosis of LMC was established ante-mortem in 16 patients, and cerebral sings and symptoms (headache, mental disorder) were most frequent, although cranial sings and symptoms were rare. Median survival (MST) was 3 months with ante-mortem diagnosis, one month with post-mortem diagnosis, and there was no significant difference. The MST was 6 months with operation, 2 months without operation, also without statistical difference.<BR>We must consider that earlier diagnosis and combined modality can improve MST of the LMC patients, though it is a rare complication.
特定非営利活動法人日本肺癌学会の論文