Pharmacokinetics of Carboplatin and Etoposide in a Hemodialysis Patient with Small Cell Lung Carcinoma.
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概要
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The pharmacokinetics of intravenously administrated carboplatin (CBDCA) and etoposide (VP-16) were studied in a patient with small cell lung carcinoma (T1N0M0, Stage I) receiving regular hemodialysis for chronic renal failure. The patient was treated with carboplatin at 300mg/m<SUP>2</SUP> on day 1 and etoposide at 50mg/m<SUP>2</SUP> on day 1 and day 3 via intravenous drip infusion for 1 hour. Hemodialysis was performed 2 hours after the start of administration for 4 hours. The pharmacokinetic results revealed that similar pharmacokinetic curves to those of patients with normal renal function were obtained using this regimen. No severe side effects were observed. These observations suggest that this regimen is a safe and useful chemotherapy regimen against malignant disease in patients undergoing regular hemodialysis.
- 特定非営利活動法人 日本肺癌学会の論文
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