A Case of Primary B Cell Lymphoma of the Lung.

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A 50-year old man was admitted for evaluation of an abnormal shadow on his chest X-ray film, consisting of a mass containing an air-bronchogram. Transbronchial lung biopsy revealed interstitial infiltration of small lymphocytes.<BR>Right lower lobectomy was performed on the suspicion of primary pulmonary lymphoma or pseudolymphoma. Conventional immunoperoxidase staining (PAP) showed monoclonal proliferation of B lymphocytes. Flow cytometry revealed that CD19- and CD20-positive lymphocytes were prominent, and that IgM was the most common surface marker. A diagnosis of small lymphocytic lymphoma, B-cell type, were made. Southern blot analysis showed clonal rearrangement of the light chain and heavy chain of the immunoglobulin gene, which supported the diagnosis.
特定非営利活動法人日本肺癌学会の論文