A Resected Case of Primary Large Cell Lung Cancer Producing Alpha-Fetoprotein.
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概要
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We report a case of a primary lung cancer which showed markedly elevated serum alpha-fetoprotein (AFP) levels. A 54-year-old man with a chief complaint of cough and a lesion on chest roentgenogram, was admitted to our department for further examinations and possible surgery. Both chest roentgenogram and chest CT demonstrated a dense mass in the upper lobe of the left lung located near the bifurcation of B<SUP>1+2</SUP> and B<SUP>3</SUP>a+b.A bronchofiberscopic examination showed slight stenosis of the orifice of B<SUP>1+2</SUP>c but could not detect the tumor. Bronchofiberscopic transbronchial biopsy and curetting were performed, but no malignant cells were identified either pathologically or cytologically.The serum level of AFP was markedly high at 15, 210ng/ml, but all other tumor markers, including CEA, SCC, CA19-9, and HCG, were within the normal range. There was no detectable lesion in the liver, testes, mediastinum, stomach, or any other organ.Upper lobectomy of the left lung was performed under the diagnosis of primary lung cancer.Microscopic examination of the resected tumor confirmed anaplastic large cell carcinoma.These findings were considered to resemble so-called "hepatoid adenocarcinoma" .Immunohistochemical staining using anti-AFP antibody revealed prominent AFP granules in the cytoplasm of the tumor cells. By one month after operation the serum AFP levels had decreased to within the normal range. There has been no evidence of any tumor recurrence or metastasis, and serum AFP level has remained within the normal range for one year since operation.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
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