Analysis of Lectin Affinity Profiles in A Case of Adenocarcinoma of the Lung Associated with Elevated Alpha-fetoprotein in Serum and Sputum.

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We report a case of adenocarcinoma of the lung that was strongly suggested to have produced alpha-fetoprotein (AFP). Sputum cytology and TBLB showed adenocarcinoma. Serum AFP was 230ng/ml and the concentration of AFP in sputum was 120ng/ml. Liver cirrhosis, hepatocellular carcinoma, carcinomas of gastrointestinal tract, mediastinal tumor and testicular tumor were excluded in the present case. These results indicated the present case to be a primary lung cancer producing AFP.<BR>The concanavalin A (Con A) non-reactive fraction rate for serum AFP was 56%. The lentil agglutinin (LCH) strongly reactive and weakly reactive subfraction were 36% and 50% respectively.<BR>In summary, our case and 13 previously reported cases in Japan in which AFP was produced by primary lung cancer did not have uniform affinity for Con A and were seemed to have LCH binding properties. These results resembled those of yolk sac tumor and gastrointestinal carcinomas.<BR>At present, we consider that the study of lectin affinity of AFP does not have any obvious clinical significance to differentiate primary lung cancers from metastatic malignant tumors.
特定非営利活動法人日本肺癌学会の論文