Hyperplastic Foci of Distal Airway Epithelium in Residents of Areas where the Incidence of Lung Cancer is High, in Particular Okinawa.

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• Resected lungs obtained of residents of Okinawa, where lung cancer incidence is higher than other areas of Japan, were examined histopathologically and compared with several materials from residents of Chiba, where the incidence of lung cancer is relatively low. The lungs from Okinawa had multiple hyperplastic foci of distal airway epithelium and their degree of severity was high. Although the incidence of lung cancer among residents of Nagasaki in Kyushu was high, the frequency of hyperplastic foci of the lungs obtained from autopsy cases in Nagasaki was lower and the severity was less than in Okinawa residents. Therefore, the high incidence of hyperplastic foci is not specific to people in areas where lung cancer is more common, but to Okinawa residents. Hyperplastic foci were observed more frequently in the lungs with adenocarcinoma than in those with squamous cell carcinoma and atypical hyperplastic foci closely resembled adenocarcinoma histologically. The severity of hyperplasia increased with age. This tendency reflected the trend that the incidence of lung cancer increases with age. We could not demonstrate that the hyperplastic foci were precancerous lesions, but it was suggested that they might contribute to the occurrence of lung cancer. There was no relationship between smoking and the occurrence of hyperplastic foci and hyperplastic foci were also observed in the lungs of stray dogs in Okinawa. Therefore, unknown external causes are suggested to be involved in the high incidence of lung cancer in Okinawa.

• 特定非営利活動法人 日本肺癌学会の論文

特定非営利活動法人 日本肺癌学会 | 論文

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