Pathological Study to Investigate the Mechanism of Cavity Formation and Cyst Formation in Pulmonary Adenocarcinoma.

概要

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The frequency and mechanism of tissue defects seen in adenocarcinomas were examined pathologically. Sixty-four macroscopic tissue defect cases were seen among 428 resected tumors. The male: female ratio was nearly the same and the mean age was 57. The causes of tissue defect and their frequency were as follows: a) Cavity formation due to ischemia was seen in 20 cases, and these were mostly composed of poorly differentiated adenocarcinoma with massive necrosis; b) Cyst formation due to tissue destruction by cancer invasion was seen in 30 cases, and was composed of moderately and well differentiated ones; c) Stretch disruption due to mucus retention was found in 5 cases and was composed of mucous secreting cells; d) Cancer invading preexisting bullae or honeycombing was seen in 3 cases; e) Others accounted for 6 cases. By macroscopic and histological examinations, it was thought that well and moderately differentiated adenocarcinoma can cause destruction of lung structure through its growth, and it is the mechanism of cyst formation.
特定非営利活動法人日本肺癌学会の論文