Neo-adjuvant Therapy for N2 Non-small Cell Carcinoma.
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概要
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Among 34 patients with CN2M0, who were hospitalized in our department since July 1987, 11 patients were treated with neo-adjuvant therapy. The average age of the patients was 55.0 years old. Eight patients were male and 3 were female. Pathologically, the patients were classified as follows: adenocarcinoma, 7 patients; squamous cell carcinoma, 3 patients; large cell carcinoma, 1 patient. The carcinoma was clinical stage IIIa in 10 patients, and Mb in one patient.<BR>The effectiveness rate of pre-operative chemotherapy was 53.8%, and the highest pathological effect was Ef. 2. All patients underwent surgical operations, curative operations in 4 patients, and non-curative operations in 7 patients. Post-operative complications were experienced by 5 patients. The three year-survival rate was 28.4%, and the MST was 24.6 months. Five patients who are surviving at present show no signs of recurrence. The three-year survival rate of the PR group (n=6) was 37.5%, and that of the NC group (n=5) was 28.6%. This difference was not statistically significant. The three-year survival rate of the curative operation group (n=4) was 100%, and that of the non-curative operation group (n=7) was 0%. This difference in survival rates was statistically significant (p<0.05). Localized recurrence has occurred in 1 patient, and distant metastasis in 4 patients.<BR>Although current chemotherapy is not sufficiently effective, patients who undergo curative operations after chemotherapy are expected to have good prognoses.
- 特定非営利活動法人 日本肺癌学会の論文
特定非営利活動法人 日本肺癌学会 | 論文
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