A Case of Large Cell Carcinoma of the Lung with Marked Leukocytosis and Thrombocytosis Producing Colony stimulating Factor.
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概要
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A 42-year-old male was admitted to our hospital complaining of general fatigue and fever. The chest roentgenogram showed an oval shadow in the right upper lung field with involvement of the chest wall. The white blood cell count increased to 60, 600/mm<SUP>3</SUP>, and the platelet count 736, 000/mm<SUP>3</SUP> on the day before operation. Under a diagnosis of large cell carcinoma of the lung, c-T 3 N0 N0, right upper lobectomy and R2-lymphnode dissection were performed with chest wall resection. White blood cell count, platelet count and tumor markers decreased to normal levels after surgery. The pathological examination showed large cell carcinoma of the lung (giant cell type). Tumor cell lines were established from the tumor tissue obtained by surgery. Following transplantation in nude mice and measurement of CSF (GM-CSF, IL-6) by ELISA in tumorconditioned medium, it was suggested that leukocytosis and thrombocytosis in this case could be due to the production of GM-CSF and IL-6 by tumor cells. This case of large cell carcinoma of the lung producing colony stimulating factor (CSF) was described with reference to the Japanese literature.
- 特定非営利活動法人 日本肺癌学会の論文
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