Argyrophil Nucleolar Organizer Regions in Small-sized Adenocarcinomas of Peripheral Lung, with Reference to Prognosis.

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Fifty-two cases of small-sized adenocarcinomas less than 3 cm of peripheral lung, which were surgically resected, were investigated in terms of argyrophil nucleolar organizer regions (AgNORs) to evaluate correlation to histopathological findings and prognosis. Nuclear atypia and histologically defined mitotic index correlated well with mean numbers of AgNORs per cell (P<0.01), but there was no significant relationship between histological differentiation of tumor or pathological grade. When the cases were divided into 3 groups, including a lower group (AgNORs<2.5), medium group (2.5≤AgNORs<4.0) and higher group (4.0≤AgNORs), the survival curves of 3 groups showed statistically significant differences (P<0.05), that is, the cases in the lower group had longer survival time than those in the higher group, but there was no significant difference in survival time among 30 cases of stage I, even if divided into 3 groups in the same manner.
特定非営利活動法人日本肺癌学会の論文