An autopsy case of combined lung mesenchymal chondrosarcoma and squamous cell carcinoma associated with multiple neurofibromatosis.

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A 80-year-old male had complained of cough and general fatigue. The chest roentogenogram showed a mass shadow in right S<SUP>3</SUP>. Fiberoptic bronchoscopy revealed a white necrotic polypoid tumor obstructing the orifice of right B3. Right upper lobectomy and lymph node dissection was performed. Histological examination of the resected specimen showed that the tumor was composed of mesenchymal chondrosarcoma and moderately differentiated squamous cell carcinoma. Since these two were separate, this case was considered double lung carcinoma. In spite of postoperative chemotherapy, he died of metastatic brain tumor, pneumonia and DIC after six months. Autopsy revealed multiple skin neurofibromatous lesions, and that the mesenchymal chondrosarcoma did not originate from bones or soft tissue. Metastases to the cerebrum, small intestine and mesenteric lymph nodes were recognized. We reported a rare double lung carcinoma associated with multiple neurofibromatosis.
特定非営利活動法人日本肺癌学会の論文