A case of small cell carcinoma of the lung with osteoplastic bone metastasis.
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概要
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A case of small cell carcinoma of the left lower lung with osteoplastic bone metastasis in a 62-year-old man was reported. Before treatment, bone roentgenograms were normal, except one bone scan showed multiple uptake. After 4 courses of chemotherapy, osteoplastic bone changes were detected in roentgenograms. At that time a bone scan demonstrated multiple cold lesions, corresponding to osteoplasic bone lesions. At autopsy, spongy bone of the vertebra was partially replaced by compact bone, and marked trabecular new-bone formation was seen around the tumor cell nests and fibrotic tissue. We considered that these osteoplastic bone changes might be due to the influence of some local factors in the agents healing process of necrotizing metastatic cancers caused by chemotherapeutic agents.
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