A case of alpha-fetoprotein-producing large cell carcinoma of the lung.

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A 72 year-old man was admitted to our hospital on 14 September 1984, complaining of dry cough and weight loss. Chest X-ray film revealed a large mass shadow on the right middle lung field. Trans-bronchial brushing and biopsy specimens showed large cell carcinoma.<BR>Serum AFP level was elevated to 37, 400 ng/ml, but laboratory data of liver function showed no abnormality. He died after 4 months in spite of chemotherapy and irradiation.<BR>Findings of the autopsy revealed a destroyed tumor mass, probably as a result of therapy and pleuritis carcinomatosa, there was no metastasis in the liver or other organs. The immunoenzyme labelling technique using ABC (Avidin-biotin complex) method showed AFP in the lung cancer cells. We concluded that these findings suggest that AFP was produced in the tumor tissue.
特定非営利活動法人日本肺癌学会の論文