Two cases of resected mediastinal malignant germ cell tumors following cisplatin, vinblastine, and bleomycin combination chemotherapy.

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We experienced two cases of mediastinal malignant germ cell tumors which were resectable following cisplatin, vinblastine and bleomycin (PVB) combination chemotherapy. The first case was a 30 year-old man with a complaint of susceptibility to fatigue and shoulder stiffness The second case was a 37 year-old man who complained of bloody sputum and left chest pain. At admission, the serum alpha-fetoprotein was markedly elevated (5000 and 200 ng/ml) in both cases and serum human chorionic gonadotoropin was also elevated (36 ng/ml) in the second case.<BR>After two courses of modified PVB chemotherapy, the serum tumor markers were normalized in both cases.<BR>The markedly decreased mediastinal tumor masses were then resected. Viable tumor cells were not present in the resected tumors. Both patients are free of disease at present, 6 and 27 months after the initial treatment.<BR>It was considered that PVB chemotherapy with surgical resection was extremely effective approach for the treatment of malignant germ cell tumor of the mediastinum.
特定非営利活動法人日本肺癌学会の論文