Serum selenium and vitamin E and A concentrations in families of lung cancer patients.

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Whether serum selenium and vitamin E (tocopherol) and A (retinol) concentrations were related to familial factors or not was examined in healthy families of lung cancer patients.<BR>Family members (115 sons and daughters of 55 patients with primary lung cancer) were found to have a trend towards lower serum selenium levels (0.116±S.D. 0.024μg/ml, p<0.1); particularly so in families of adenocarcinoma patients (0.111±0.019μg/ml, p<0.01) than that (0.122±0.014 μg/ml) of age and sex-ratio matched controls who did not have a familial history of cancer patients as far as second-degree relatives.<BR>The serum vitamin E level (11.85±2.85μg/ml) was significantly lower in the families of adenocarcinoma patients than in the controls (13.92±2.99 μg/ml, p<0.01). There was no difference in serum vitamin A levels between families of lung cancer patients and the controls. Serum selenium and vitamin E and A levels were significantly lower (p<0.001) in lung cancer patients than in controls.<BR>These data suggest that there are familial factors in serum selenium and vitamin E levels in primary lung cancer.
特定非営利活動法人日本肺癌学会の論文