Multiple primary cancer with primary lung cancer in 986 autopsy cases.

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• To analyse the clinical feature of multiple primary cancer associated with primary lung cancer, 986 autopsied malignant cases were studied. Eighty-one cases were multiple primary cancer cases. Twenty-eight out of the 206 lung cancer cases (13.6%) were combined with another primary cancer, and this constituted 34.6% of 81 multiple primary cancers. They consisted of 10 squamous cell carcinomas, 11 adenocarcinomas, 5 small cell carcinomas and 5 large cell carcinomas (including 3 multiple lung cancers), and the incidence in each histological type was from 13 to 16%.<BR>Eight cases of 15 overt second cancers had an abnormal shadow on chest X ray films, and 7 out of 8 were the second primary lung cancers. However they were diagnosed as tuberculomas in 2, solitary metastatic lung cancer in 1, multiple metastatic lung cancers in 3 and primary lung cancer in 1.<BR>Median survival time (MST) of 25 cases who died of cancer was 8 months. There was statistical significance (p<0.0178) between the survival curve of preceeding lung cancer cases (MST-7 months) and that of succeeding lung cancer cases (MST-26 months). The median survival time after the recognition of the second lung cancer in the succeeding lung cancer cases (MST =4 months) was shorter than that of the preceeding lung cancer cases (MST-7 months) with statistical significance (p<0.0004).<BR>In the clinical examination of malignant diseases, more attention should be paid to the possibility of second primary cancer because earlier diagnosis and aggresive treatment may prolong the survival time.

• 特定非営利活動法人 日本肺癌学会の論文

特定非営利活動法人 日本肺癌学会 | 論文

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