Combination therapy of large dose of Carboquone and radiation for small cell carcinoma of the lung.

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Fourteen patients with small cell carcinoma of the lung were treated with large doses of Carboquone (CQ), i.e. 0.4mg/kg of CQ was administered at first, and 0.2mg/kg of CQ was readministered at intervals of 5 weeks, and all of them were also treated with OK-432 1 KE/body daily. Twelve of these patients had also radiotherapy within 1 week after the second shot of CQ. After chemotherapy, two cases showed complete response and 9 showed partial response. The response rate was 79%. After radiotherapy, 5 patients showed CR and 7 patients showed PR. Then the response rate was 100%. The median survival time was 39 weeks for all cases, 56 weeks for 9 cases of limited disease and 26 weeks for 5 patients of extensive disease. Complete responders survived longer than partial responders (MST: 58 weeks versus 33 weeks). Adverse reactions to chemotherapy were leukopenia (>3000/mm3, 43%), thrombocytopenia (>100000/mm3, 50%), anorexia, etc., but were generally reversible. No other severe side effects were observed. Our results suggest that the administration of a large dose of CQ is recommended for treatment of small cell carcinoma and the combination of radiotherapy with chemotherapy is more effective.
特定非営利活動法人日本肺癌学会の論文