Nuclear DNA content of small cell carcinoma of the lung and its relationship to response to chemotherapy.

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The relationship between the nuclear DNA contents of tumor cells obtained by brushing via bronchoscopy and the response to chemotherapy of 22 patients with small cell carcinoma of the lung was investigated. The nuclear DNA content was measured at 550 nm using a microspectrophotometer.<BR>The DNA histogram pattern was classified into either "Type A", containing a higher proportion of GoGI-phase cells, or "Type B", containing a higher proportion of S and/or G2M-phase cells. All patients were treated by combination chemotherapy of Vincristin, Cyclophosphamide and Adriamycin.<BR>Of the 8 patients who responded well to chemotherapy, 6 patients (75%) had the Type B histogram pattern, and 2 patients had the Type A histogram pattern.<BR>Of the 14 patients who did not respond to chemotherapy, 11 patients (78.6%) were Type A and 3 patients were Type B. Small cell carcinoma with the Type A histogram pattern were regarded as poor responders whereas the cases with Type B were good responders.<BR>These results indicated that the nuclear DNA content of small cell carcinoma may indicate the choice of drugs and help to evaluate the effect of chemotherapy.
特定非営利活動法人日本肺癌学会の論文