Effect of intrapleural administration of adriamycin or adriamycin with OK-432 in carcinomatous pleu

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• Thirty-two patients with carcinomatous pleurisy were treated with intrapleural administration of adriamycin (A. D. R.) alone or the combination of A. D. R. with OK-432.<BR>After the pleural fluid was aspirated as much as possible through a 17 gauge elaster, A. D. R. or A. D. R. plus OK-432 was instilled into the pleural space once a week.<BR>Of the total 32 patients, 16 were subjected to infusion of 10-40 mg of A. D. R. and 16 patients to the injection of 20 mg of A. D. R. with 5KE of OK-432.<BR>The former group comprised 12 patients with lung cander (8 adenocarcinoma, 2 squamous cell carcinoma, and 2 small cell carcinoma) and 1 each with mammary cancer, fibrosorcoma, multiple myeloma, and reticulosarcoma.<BR>The latter group comprised 15 patients with lung cancer (3 squamous cell carcinoma, 9 adenocarcinoma, 2 small cell carcinoma, and 1 large cell carcinoma), and 1 ovarian cancer.<BR>Of 16 patients treated with A. D. R. alone, 15 (93.8%) demonstrated cytolozically negative in the pleural fluid and the fluid was eliminated in 10 out of 16 patients (62.5%).<BR>The mean total dose of A. D. R. administered until these effects were obtained was 59.3 mg and the mean period of time was 3.1 weeks.<BR>Of the 16 patients the A. D. R. plus OK-432, 15 (93.8%) showed cytologically negative in the pleural fluid, and the fluid was eliminated in 12 (81.2%).<BR>In this group the mean total dose of A. D. R. until the effects were obtained was 42.6mg and the mean period of time was 2.2 weeks.<BR>In the latter group the mean total dose of A. D. R. was less and the period of time was shorter than those of the former group.<BR>The A. D. R. instilled in the pleural space was maintained In more than 20% of the initial concentration immediately after the instillation with traces in the blood and urine after 24 hours. The side effects were minimal and there was no complication.

• 特定非営利活動法人 日本肺癌学会の論文

特定非営利活動法人 日本肺癌学会 | 論文

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