A Case of the Oat-cell Carcinoma of the Lung with Ectopic ACTH Production Proved by the High Level of ACTH in Tumor Cells in Pleural Fluid

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A typical case of the oat-cell carcinoma of the lung with ectopic ACTH production was reported. The signs compatible for Cushing's syndrome manifested clinically later on the second admission, though they were undetectable clinically and also endocrinologically on the first admission. The reason for this delayed appearance of the syndrome are not clear and of matter of discussion. Although ectopic production of ACTH was confirmed histologically with the assay of the hormone in tumor tissue obtained at the autopsy and endocrinologically in the medium of the tumor cell culture, the high level of ACTH was detected in the tumor cells collected from the carcinomatous pleural fluid before her death. The determination of the hormone in the tumor cells in the fluid from body spaces may become a histological support for establishing clinical diagnosis of the ectopic hormone production by neoplasma.
特定非営利活動法人日本肺癌学会の論文