For a sophisticated application of catecholamine kinetic data to work load evaluation.:data to work load evaluation

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Eight male adults (20-23 years of age) were induced to perform a mild (1.5 Kp) upright ergometer exercise for 5 minutes. The aforesaid subjects' BP and HR, before (0 min as the initial point), during (2, 4, 5 min) and after (7, 10, 15, 20, 25, 30, 60, 90, 120, 150, 180 min) the exercise were recorded sequentially. At the same time points, (except for 15 min), blood specimens were collected from an indwelling anticubital catheter and the plasma noradrenaline level (PNA) was measured by high performance liquid chromatography with electrochemical detection. The sequential changes of BP, HR and PNA were simulated in our mathematical model of multiexponential functions as follows: ΣAi·exp (-Bi·t) (t; time). Furthermore the relations among those parameters derived from the above simulation procedure such as Aij and Bij were analysed. In these equations i and j designate respectively individual function and physiological indicators, which include BP, HR and PNA. The results from the statistical analysis of the relationships existing among the parameters suggest that the BP change is one of the best indicators of stress in the sympathetic nervous system after exposure to physical stress.
日本医科大学医学会の論文