On the Occurrence of Myelocytes in the Secondary Nodules of Lymph Node, with Special Reference to Their Origin
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1. Following intravenous injection of a single large dose of saponin into splenectomized and non-splenectomized rabbits, the chronological changes in the mode of occurrence of myelocytes in the mesenteric and popliteal lymph nodes were pursued. Besides, the lymph nodes from some rabbits treated with adrenal cortical hormone were examined.2. After saponin injection, myelocytes occurred in the lymph nodes of splenectomized rabbits in much greater numbers than in those of non-splenectomized rabbits.3. In a period earlier than 24 hours after saponin injection, the myelocytes occurred for the most part intravascularly in the postcapillary veins and other small blood vessels (Fig. 1). At 48 hours, the process of emigration of myelocytes through vascular wall from inside to outside of the vessels could be traced (Fig. 2).4, During the period from 5 to 14 days after injection, foci of myelocytes appeared often in large numbers in the medullary cords (Fig. 8). These cells also appeared in the pale centers of secondary nodules, either scattered singly or grouped in clusters (Figs. 5-7). Such myeloid transformation of secondary nodules was encountered in 3 out of 7 splenectomized rabbits and in 1 out 8 non-splenectomized ones.5. In the pale center of secondary nodules, the myelocytes first appeared also intravascularly in the dilated capillary (Fig. 3-4), but there seemed to be other cases in which the myelocyte foci, first formed in the cortex, became surrounded secondarily by a layer of densely aggregated small lymphocytes, assuming the appearnce like secondary nodules (Fig. 6-7).6. In the pale center of secondary nodules, there was no evidence in favor of a local formation of myelocytes through metaplasia from the so-called "grem-center cells."7. The above mentioned results are interpreted as evidence for colonization of myelocytes from the bone marrow into the lymph node, and even into its secondary nodules, by hematogeneous metastasis.
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国際組織細胞学会 | 論文
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