Brain Ultrastructure of the Newborn Rat in Dehydration
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概要
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Electron microscopic observation was made on the changes in the cerebral cortex of the newborn and developing rat brain caused by dehydration. Rats ranging in age from one to four days were kept unfed for from 24 to 96 hours.1. In the dehydrated animals, the brain capillaries became irregular in outline and the endothelial cells swelled with an increased cytoplasmic density. Vacuole formation in the endothelial cytoplasm became conspicuous and the basement membrane increased in width. Disappearance of the thin fold which overlaps endothelial cells may be recognized. The pericapillary glial processes may be destructed. These changes appear to represent a progressive reaction to the dehydration and to indicate an increased permeability in the blood brain barrier. As the dehydration goes on, these changes become more conspicuous, but in severely affected cases, swollen endothelial cells gradually lose their density with a decrease in the number of organelles.2. The most evident and constant changes in the nerve cells are vacuolar cisternae of the rough surfaced endoplasmic reticulum, derangement of the accumulations of the reticulum cisternae as Nissl bodies and increased vesicles in the cytoplasm. Mitochondrial degeneration is not constant. These cytologic damages are recognizable in all dehydrated animals though varying considerably in degree. The vacuole formation becomes more conspicuous as the dehydration goes on.3. Oligodendroglial cells show considerable changes such as vesiculation and vacuolation of the cytoplasm.4. No remarkable changes of intracytoplasmic organelles occur in astrocyte, but shrinkage of the cell body is observed occasionally.5. In general, cytologic changes due to dehydration are observed more frequently and strongly around the capillary.
- 国際組織細胞学会の論文
国際組織細胞学会 | 論文
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