The pharmacokinetics of the type A influenza virus medicine 'Amantazine hydrochloride' in hemodialysis patients.

概要

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During the winter of 1998-1999, many elderly Japanese died from the type A influenza virus. Although no precise reports regarding victims of flu for dialysis patients are available yet, elderly dialysis patients as compromised hosts may have had high mortality. Amantazine hydrochloride (a. h.) is an anti-Parkinsonism medicine that also has anti-Type A influenza action. Because no pharmacokinetics of a. h. in Japanese dialysis patients have been reported yet, we have evaluated the pharmacokinetics of a. h. (100mg/week) in 6 patients. From relatively high blood concentrations following hemodialysis on days 3 and 7, we speculated that the dose should be adjusted to less than 100mg/week or the interval of administration to more than one week.
社団法人日本透析医学会の論文