The mathematical analysis of the blood volume change during hemodialysis by continuously hematocrit monitoring.
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Purpose: We mathematically analysed the blood volume change during hemodialysis by continuous hematocrit monitoring using CRIT-LINE (IN-LINE DIAGNOSTICS). Methods: We measured the hematocrit and calculated the blood volume change (%BV) in eight chronic hemodialysis patients, 5 hemodialysis sessinons in each patient and studied the method of approximating %BV using the equation: %BV=b×[1-exp(cX)]-aX. Furthermore, we studied the relationship between the coefficients (a, b, c) and clinical parameters.Results: 1) Hematocrit decreased just after the start of hemodialysis and gradually increased from about 1 hour to the end of hemodialysis. Just after the start of hemodialysis, %BV increased then started to linearly decrease after about 1 hour and continued to decrease until the end of hemodialysis. 2) We approximated the linear part of %BV to the equation: y=b-aX and the curved part of the equation: y=b×[1-exp(cX)] and then gained a good correlation (r>0.95) in each part of %BV. Thus, we could approximate %BV to the equation: y=b×[1-exp(cX)]-aX. 3) Coefficient a, the slope of the linear part of %BV was 0.0859±0.0051. Coefficient b, the degree of increase of %BV, was 5.948±0.433. Coefficient c, the speed of increase of %BV, was -0.0396±0.0028. 4) As for the relationship of each coefficient to the clinical parameters, only coefficient a was significantly related to the volume removed during hemodialysis (r=0.50, p<0.05). Conclusions: %BV could be approximated to the equation: %BV=b×[1-exp(c×Time)]-a×Time. However, further studies will be needed to analyse the clinical importance of each coefficient.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
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