The use of highly sensitive parathyroid hormone(HS-PTH) in patients undergoing maintenance hemodialysis therapy.

概要

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In renal failure patients on hemodialysis, various methods are used to measure PTH blood levels including cterminal PTH (C-PTH), (1-84) PTH (INS-PTH) and highly sensitive PTH (HS-PTH), but it is important to study the features of each method in order to gain a clear understanding of the pathological conditions of secondary hyperparathyroidism.In the present study, these three methods were compared in chronic hemodialysis patients, and the following results were obtained. 1. HS-PTH showed a high correlation with INS-PTH and C-PTH (r=0.774 and 0.967), C-PTH showed a low correlation with INS-PTH in cases where INS-PTH≤120pg/ml (r=0.488). 2. In a comparison of the reproducibility at monthly intervals in the same patients without any changes in treatment, HS-PTH showed the smallest variations. 3. In cases which showed a gradual increase in C-PTH in the blood over one year of observation, INS-PTH showed higher values than HS-PTH. And in cases of a gradual decrease in serum C-PTH over the same period of observation, INS-PTH showed lower values than HS-PTH.
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