Endogenous ligands and the "chronicity" of renal failure.
スポンサーリンク
概要
- 論文の詳細を見る
We have investigated whether or not the accumulation of the endogenous ligands 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) and indoxyl sulfate (IS) in serum reflects the "chronicity" of renal failure. We have also evaluated the value of measuring serum concentrations of CMPF and IS in differentiating between non-dialysis chronic renal failure (CRF), acute on CRF (A on CRF) and acute renal failure (ARF), which is sometimes difficult clinically.Serum concentrations of CMPF and IS were well correlated with serum creatinine concentrations (Cr) in both dialyzed and non-dialysis CRF. In ARF, CMPF levels were low when compared with Cr and blood urea nitrogen (BUN), but IS levels were not necessarily lower when compared with Cr and BUN. The molar ratios of CMPF/creatinine and CMPF/urea of non-dialysis CRF and A on CRF were significantly higher than in ARF, but there were no statistically significant differences in the molar ratios of IS/creatinine and IS/urea in non-dialysis CRF, A on CRF and ARF. These results indicate that the accumulation of endogenous ligands with a strong affinity for serum albumin, such as CMPF, reflects the "chronicity" of renal failure and the measurement of serum concentrations is of clinical value in differentiating between ARF and CRF. However, the accumulation of ligands having relatively weak affinity for serum albumin, such as IS, does not necessarily reflect the "chronicity" of renal failure.
- 社団法人 日本透析医学会の論文
社団法人 日本透析医学会 | 論文
- 4．血液浄化療法の生体適合性と腎性貧血
- PD-HD併用療法においての腎機能保護の可能性 : 第51回日本透析医学会ワークショップより
- 腹部大動脈人工血管の仮性動脈瘤破裂，および右大腿回旋動脈の仮性動脈瘤破裂をきたした血液透析患者の1例
- 5．透析患者のインスリン抵抗性と腎性貧血
- 摘出腫瘤の病理組織標本所見より頸椎腫瘍状石灰沈着症 (cervical tumoral calcinosis) と診断し得た維持透析患者の1例