Study on changes in blood gold concentration and efficacy & safety of oral gold compound (auranofin) as replacement of injectable gold (GST) in patients with rheumatoid arthritis.

概要

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To determine if rheumatoid arthritis patients on gold sodium thiomalate (GST) can be maintained on auranofin (AF), we examined a group 111 patients, who had been stable on GST.<BR>The patients were randomized to receive either AF 6 mg daily, or continued GST. Patients eligible for study showed no difference in clinical outcome after 6 months of treatment.<BR>On-therapy conditions in the 2 groups were similar, with the exception of diarrhoea in 29.8% of the AF-treated group.<BR>And there were no correlation between blood gold concentration and safety & efficiency.<BR>This study shows that AF may be substituted for GST during rheumatoid arthritis therapy.
日本炎症・再生医学会の論文