Inhibitory effect of LM-001 on the biosynthesis of prostaglandin E2 in carrageenin-induced inflammatory exudate at the rat hind paw.
スポンサーリンク
概要
- 論文の詳細を見る
Quantities of prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) in carrageenin-induced inflammatory exudate at the rat hind paw were measured by the radioimmunoassay method. PGE<SUB>2</SUB> level increased rapidly and peaked 3 hours after treatment of carrageenin. Intravenous administration of LM-001, indomethacin (IM) and aspirin DL-lysine (VP), given 1 hour after treatment of carrageenin, significantly lowered the PGE<SUB>2</SUB> level in the exudate (sampled 3 hours after treatment of carrageenin), dose-dependently. ID<SUB>50</SUB> value (95% confidence limits) of each drug was as follows; LM-001: 1.2 (0.2-6.5) mg/kg, VP: 26.9 (4.5-161.2) mg/kg and IM: 0.2 mg/kg (95% confidence limit was impossible to be calculated) . These drugs very significantly reduced the PGE<SUB>2</SUB> concentration in exudate, but the edema formation was not always suppressed to the same degree of PGE<SUB>2</SUB> biosynthesis. These findings suggest that antiinflammatory potencies of these drugs are unable to account for only the inhibitory potencies of PGE<SUB>2</SUB> biosynthesis in this model.
- 日本炎症・再生医学会の論文
日本炎症・再生医学会 | 論文
- 新規キノリノン誘導体TA-270の炎症性気道疾患に対する効果
- Salazosulphapyridine, Predonizolone の好中球機能に及ぼす影響と Sodium ferrous citrate との併用効果についての検討
- Sodium ferrous citrate の好中球機能に及ぼす影響
- Mesalazine(Pentasa) の好中球機能に及ぼす影響と Sodium ferrous citrate(SFC) との併用効果についての検討
- 非ウイルスベクターによる細胞標的法の開発